Erik Henriksen in his Muscle Metabolism Laboratory

Research Interests

• Regulation of glucose transport in muscle by insulin and contractions
• Role of glycogen synthase kinase-3 in the etiology of skeletal muscle insulin resistance
• Role of oxidative stress in the development of defective insulin signaling and glucose
   transport in skeletal muscle
• Pharmaceutical and nutriceutical interventions for the treatment of insulin resistance of
   skeletal muscle glucose transport
• Adaptive responses of carbohydrate and protein metabolism in muscle to exercise,
   simulated weightlessness, and denervation

Graduate Program Affiliations

Biochemistry and Molecular & Cellular Biology

Nutritional Sciences

Physiological Sciences

Publications

Henriksen EJ, Teachey MK, Lindborg KA, Diehl CJ, Beneze AN. May 2008. The high fat-fed lean Zucker rat: a spontaneous isocaloric model of fat-induced insulin resistance associated with muscle GSK-3 overactivity. Am J Physiol Regul Integr Comp Physiol, 294:R1813-R1821

Dokken BB, Saengsirisuwan V, Kim JS, Teachey MK, Henriksen EJ. Mar 2008. Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3. Am J Physiol Endocrinol Metab, 294:E615-E621

Harrell NB, Teachey MK, Gifford NJ, Henriksen EJ. Oct 2007. Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithium. Arch Physiol Biochem, 113:221-7

Henriksen EJ. Sep 2007. Improvement of insulin sensitivity by antagonism of the renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol, 293:R974-80

Henriksen EJ, Teachey MK. Jul 2007. Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats. Metabolism, 56:931-8

Henriksen EJ Dokken BB. Nov 2006. Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. Curr Drug Targets, 7:1435-41

Kim JS, Saengsirisuwan V, Sloniger JA, Teachey MK, Henriksen EJ. Sep 2006. Stimulation of muscle glucose transport by an oxidant stress: roles of insulin signaling and p38 MAP kinase. Free Rad Biol Med, 41:818-824

Dokken BB, Henriksen EJ. Jun 2006. Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in pre-diabetic obese Zucker rats. Am J Physiol Endocrinol Metab, 291:E207-E213

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